Research through the Buck Institute for Research on Aging and McMaster University in Hamilton, Ontario indicates that massage therapy reduces inflammation of skeletal muscle acutely damaged through exercise. The study provides evidence for the benefits of massage therapy for those with musculoskeletal injuries and potentially for those with inflammatory disease, according to the lead author of the research.
- The study found evidence at the cellular level that massage therapy may affect inflammation in a way similar to anti-inflammatory medications.
- The researchers “found that massage activated the mechanotransduction signaling pathways focal adhesion kinase (FAK) and extracellular signal–regulated kinase 1/2 (ERK1/2), potentiated mitochondrial biogenesis signaling [nuclear peroxisome proliferator–activated receptor γ coactivator 1α (PGC-1α)], and mitigated the rise in nuclear factor κB (NFκB) (p65) nuclear accumulation caused by exercise-induced muscle trauma.”
J. D. Crane, D. I. Ogborn, C. Cupido, S. Melov, A. Hubbard, J. M. Bourgeois, M. A. Tarnopolsky, Massage Therapy Attenuates Inflammatory Signaling After Exercise-Induced Muscle Damage. Sci. Transl. Med. 4, 119ra13 (2012).